Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the Laboratory Animals editorial office as follows: Editorial Office: LAeditorial@sagepub.co.uk, Individual Subscription, Combined (Print & E-access), Institutional Subscription, Combined (Print & E-access), Institutional Backfile Purchase, E-access (Content through 1998). A consensus sequence was obtained and compared with the analogous gene sequence data from rat-origin CAR bacillus isolates. The international journal of laboratory animal science, technology, welfare and medicine, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the care and use of animals in research. Only manuscripts of sufficient quality that meet the aims and scope of Laboratory Animals will be reviewed. The statements must: Where appropriate, SAGE reserves the right to deny consideration to manuscripts submitted by a third party rather than by the authors themselves. Likewise, females in the 12L:12D group had luteinized follicles and elevated progesterone in November which were not noted in natural photoperiod animals and which were similar to those observed during the spring in unbred females under normal conditions. A 24-month study assessed the carcinogenic potential of the nephrotoxic mycotoxin ochratoxin A (OA) in B6C3F1 mice. Similar depressed cardiovascular responses were observed in conscious animals infected with Pichinde virus. Inbred (13/N Umm) and conventional (Mfi:CFDH-ML (DH) ) guinea pigs were used. The major types of cells expressing TNF-alpha and IL-1 alpha included alveolar macrophages, endothelial cells, and bronchiolar and alveolar epithelial cells. Eighty-four percent of both groups of females were fertile. These experiments evaluated the therapeutic effectiveness of radiation alone, continuous intracerebral infusions of 5-iodo-2-deoxyuridine (IUDR) alone, and a combination of both therapies. Pulmonary functions were determined for 1 minute every 10 minutes for 2 hours before and at postinoculation days (PID) 3, 6, 8, and daily thereafter until shortly before death. IMPORTANT: Please check whether you already have an account in the system before trying to create a new one. After 4.5 years of 12L:12D, food intake was measured in November and compared with that in natural photoperiod animals (Study 3). 27, 333-335, Scipioni RL, Diters RW, Myers WR, Hart SMClinical and clinicopathological assessment of serial phlebotomy in the Sprague Dawley rat. Lab Anim Sci 41: 269-273, Benson, L.M. The best assurance that a colony is SPF comes from negative results of repeated testing. In fall of 1979, a diagnosis of epizootic mousepox was confirmed in mice at the University of Utah Medical Center. Hyperventilation, increased specific pulmonary airway resistance, terminal hypoventilation, and respiratory arrest were noted in strain 13 guinea pigs infected with Pichinde virus. All contributors who do not meet the criteria for authorship should be listed in an Acknowledgements section. The histocompatibility status of the Nya:NYLAR mouse colony was studied by exchange of skin grafts between female mice. Word count for the abstract should be 250 words. The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). Of particular note, the source and full strain nomenclature of any laboratory animal stock must be specified according to international recommendations. Please ensure that a ‘Declaration of Conflicting Interests’ statement is included at the end of your manuscript, after any acknowledgements and prior to the references. Laboratory Animal Science (Lab Anim Sci) Additional details (ABSTRACT TRUNCATED AT 250 WORDS). In 2019 it started publishing contents in partnership with BMC in a renewed, fully open access format. Group differences in multiple hematologic parameters were significant. For more information please refer to our guidelines on submitting supplemental files. Browse all issues of Laboratory Animals. AALAS is a membership association of laboratory animal science professionals dedicated to the humane care and treatment of laboratory animals, as well as the quality research that leads to scientific gains that benefit people and animals. Questions may be sent to the Editorial Office at laeditorial@sagepub.co.uk. Where an article, for example, is found to have plagiarised other work or included third-party copyright material without permission or with insufficient acknowledgement, or where the authorship of the article is contested, we reserve the right to take action including, but not limited to: publishing an erratum or corrigendum (correction); retracting the article; taking up the matter with the head of department or dean of the author's institution and/or relevant academic bodies or societies; or taking appropriate legal action. Parameters evaluated included body weight, clinical signs of disease, hematologic and serum biochemical analytes, organ weights, and histopathologic features. Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38.5 to 39.5 degrees C. The time required for the temperature increase was significantly longer in the anesthetized state. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed … for identification of experimentally induced infection with Helicobacter pylori, the bacterium causing gastric ulcer in humans. The CAR bacillus isolates were further examined at the genetic level by sequencing 1,261 base pairs of the 16S rRNA gene from six CAR bacillus isolates obtained from infected rabbits. Up to 30 references. Visit http://mc.manuscriptcentral.com/la to login and submit your article online. Improving laboratory animal science and welfare requires both new scientific research and insights from research in the humanities and social sciences. Anim. The inhibition experiments using extracts of C. jejuni, C. fetus and Yersinia enterocolitica demonstrated that the established ELISA system could detect species-specific anti-C. jejuni and anti-C. fetus antibodies. Usually the principles applied will be those specified in the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes and its appendices and/or the National Research Council Guide for the Care and Use of Laboratory Animals. This is all those who: Authors should meet the conditions of all of the points above. Parasites were found in red blood cells of two long-tailed macaques (Macaca fascicularis) imported from Indonesia and housed in the Washington Regional Primate Research Center breeding colony for 7 years or longer. This journal is able to host additional materials online (e.g. Time of death of CNS tumor-bearing rats can be reliably predicted by body weight-loss patterns. No more than 4 displays (tables and/or figures). The principal necropsy finding in these monkeys, and in eight others killed for experimental purposes, was hypertrophic and hyperplastic mucinous gastropathy involving both the mucosa and submucosa. Papers should only be submitted for consideration once consent is given by all contributing authors. Anim. After artificial cerebrospinal fluid was infused into the left ventricle at 0.5 ml/h, left cerebroventricular pressure increased to 8.1 +/- 1.6 mmHg (P less than 0.01), while right cerebroventricular pressure reached 5.6 +/- 2.2 mmHg within 20 minutes. These should be up to 7,500 words including abstract, figure/table captions and references. Please note that if there are any changes to the author list at this stage all authors will be required to complete and sign a form authorising the change. The journal is published by SAGE on behalf of Laboratory Animals Ltd. ‘Laboratory Animals’ is a major international journal focused on laboratory animal science and welfare. A lean and obese strain of swine from similar genetic lineage (Duroc x Yorkshire, 50:50) have been well established and may prove ideal for this purpose. The title, keywords and abstract are key to ensuring readers find your article through search engines such as Google. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. The abstract must be unstructured and consist of a single paragraph with fewer than 250 words. Total Articles. In the rhesus monkeys, the disease was characterized by convulsive seizures of short duration and sudden death with no obvious pathologic changes observed at necropsy. Online First allows final articles (completed and approved articles awaiting assignment to a future issue) to be published online prior to their inclusion in a journal issue, which significantly reduces the lead time between submission and publication. Approximately 2 weeks after the second blood collection regimen, animals were euthanized. When reporting variability about the mean, variances, and/or discussing significance or non-significance of statistically derived values, the Zar recommendations should be considered, and claims of statistical non-significance should be accompanied by post-test power analyses whenever possible. Access to society journal content varies across our titles. Both mouse strains began ovulating at 8 h after hCG administration. 2019/2020. 39.79. That implies learning Biology, Reproduction, Physiology, Nutrition (feeds, feeding), Pathology (including disease emergence and zoonoses) and behaviour. In a tissue culture medium containing 0.5% bovine serum albumin, only the iodophore was virucidal. Key issues reported in-depth through ‘Laboratory Animals’ – the official journal of LASA. You will be asked to provide contact details and academic affiliations for all co-authors via the submission system and identify who is to be the corresponding author. On the other hand, no antibody response to C. jejuni was found in two infants from which it could not be isolated throughout the observation period. Because male and female pronuclei form 4 to 7 and 6 to 9 h respectively after insemination, the most pronuclear stage embryos should be obtained by collecting them 20 to 21 h after hCG in C.B-17/Icr-scid/scid mice and 18 to 19 h in B6SJLF1 mice. Figures supplied in colour will appear in colour online regardless of whether or not these illustrations are reproduced in colour in the printed version. Virgin and proven fertile males were mated with 1 (1:1) or 2 (2:1) virgin or proven fertile females. LabRoots is pleased to announce the 10th Annual Laboratory Animal Science Virtual Conference which will take place on February 10, 2021. were detected by immunofluorescence assay (IFA) from one infected macaque, which showed antibody cross-reactions (high titer) to B. bigemina, B. bovis, B. canis, and (low titers) to Plasmodium falciparum. Total Cites. In phase II, total calpastatin activity and total cathepsin B activity were greater in the obese pigs than in the lean pigs. However, 30 to 50 minutes later, mean blood pressure, heart rate, and cerebrospinal fluid pressure decreased abruptly, and two of four animals died. Widely distributed and discoverable globally with indexing by ESCI, MEDLINE, PubMed via PMC, and Directory of Open Access Journals. The change in binding capacity appeared to explain, at least in part, the apparent hyperthyroid-like T4 concentrations of the young dog.