Alternatively, total daily dose of 0.25 mg/kg or 8 mg/m². Serotonin and histamine antagonist; competitively inhibits H1 receptor, mediating bronchial constriction, smooth-muscle contraction, edema, hypotension, CNS depression, and cardiac arrhythmias; prevents histamine release in blood vessels and is more effective in preventing histamine response than in reversing it; may be useful in patients with syndromes sustained by histamine-producing tumors, Moderate anticholinergic activity with low sedative effect, May have some calcium-channel blocking activity, Metabolites: Quaternary ammonium glucuronide conjugate. "i have heard people take apetamin cyproheptadine to increase appetite for weight gain. Maintenance dose: 4 to 20 mg orally per day, given in divided doses Uses: -Patients with bladder neck obstruction For appetite stimulation in cats, the dose is 1 to 4 mg per cat one to two times daily. Sixteen patients were given cyproheptadine 2 to 6 mg/day for a minimum of 7 days. Cyproheptadine Vs Mirtazapine For Cats. Prescription drug information for thousands of brand, generic, and OTC medicines is available to registered members only. Objective: A systematic review identifying the use of cyproheptadine (CY) as an appetite stimulant was completed. Unintentional Weight Loss and Appetite Stimulants. Cyproheptadine doses are based on weight (especially in children and teenagers), and any changes may affect the dose. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvY3lwcm9oZXB0YWRpbmUtMzQzMzg5, View explanations for tiers and Method: Studies of any design exploring the efficacy of CY as an appetite stimulant in all age groups and populations were included. informational and educational purposes only. The recipient will receive more details and instructions to access this offer. Question: I was searching your site for more information about the use of cyproheptadine as an appetite stimulant. Cyproheptadine (also called Periactin®) is an antihistamine medicine. This medicine can cause you to have a false positive drug screening test. Contact the applicable plan provider for the most current information. Uses: View the formulary and any restrictions for each plan. -Inform patients that this drug may cause drowsiness and somnolence, and they should avoid driving or operating machinery if these side effects occur. Maximum dose: 0.5 mg/kg/day Comments: Nursing Implications The optimal dose, start time, and duration of treatment for many appetite … Both cyproheptadine and mirtazapine are commonly used appetite stimulants for cats. This study evaluated serum leptin concentrations in patients who received cyproheptadine to treat a variety of disorders. Cyproheptadine is a weak appetite stimulant, but side effects are limiting. Your veterinarian will determine the appropriate dose according to your cat’s weight. The above information is provided for general It can come as either a 0.4 mg/mL syrup or in a 4 mg oral tablet form. Cold or allergic reaction medication, sedatives, narcotic discomfort medicine, resting supplements, muscle relaxers, as well as medication for seizures, depression or stress and anxiety can include to drowsiness created by cyproheptadine. -Amelioration of allergic reactions to blood or plasma Primary outcomes of studies included were weight gain, appetite stimulation, and/or caloric/nutritional intake increase. Comments: -Doses should be individualized, with doses based on response and patient size. commonly, these are "non-preferred" brand drugs. is this a relatively safe way for weight gain?" FDA Approved: No. How Dispensed: Prescription only. commonly, these are "preferred" (on formulary) brand drugs. I recently had an evaluation with a kiddo who is taking this twice a day to increase appetite but mom doesn’t think it has helped much. -Doses should be individualized, with doses based on response and patient size. -Perennial/seasonal allergic rhinitis If you provide a urine sample for drug screening, tell the laboratory staff that you are taking cyproheptadine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 7 to 14 years: 4 mg orally 2 to 3 times a day excedrin-pm-headache-acetaminophen-aspirin-diphenhydramine-1000037 Appetite stimulants (cyproheptadine and megestrol) have been successfully used in poorly growing children, resulting in improved weight for age z-scores in the short term (two to 3 months) [52,53]. This drug is available at a higher level co-pay. The dose is not to exceed 16 mg a day. Initial dose: 4 mg orally 3 times a day. -Many patients require a daily dose … Last updated on Oct 12, 2020. -Mild, uncomplicated allergic skin manifestations of angioedema and urticaria The recommended starting dose of the drug is 1.88 mg for cats and can be given once a day in young cats. 6 No. Your list will be saved and can be edited at any time. The dose is not to exceed 12 mg a day. The drug comes in the form of 4 mg tablets or 2 mg per 5 ml syrup. Drug Name: Cyproheptadine. A: Generally acceptable. -Hypersensitivity to the active component or to any of the ingredients Controlled studies in pregnant women show no evidence of fetal risk. Compare formulary status to other drugs in the same class. 1048596-overview Species: Dogs, Cats. It is also used as an appetite stimulant to help adults and children gain weight, according to a report in the Journal of Pediatric Gastroenterology and Nutrition. to maintenance dose over 3wk renal dosing [see below] renal impairment: not defined, caution advised 2 to 6 years: 2 mg orally 2 to 3 times a day Patient advice: -Maximum dose: 16 mg/day 2010 Share cases and questions with Physicians on Medscape consult. -Stenosing peptic ulcer Data sources include IBM Watson Micromedex (updated 3 May 2021), Cerner Multum™ (updated 4 May 2021), ASHP (updated 3 May 2021) and others. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. To treat allergies and allergic reactions, cyproheptadine is dosed at 0.15 to 1 mg per poung (0.3 to 2 mg/kg) twice daily in dogs, and 2 mg per cat twice daily. Common Name: Periactin®. Consult WARNINGS section for additional precautions. Tell your doctor if you have serious side effects of Cyproheptadine including: mental/mood changes (such as restlessness, confusion, hallucinations), shaking , difficulty urinating, or ; fast/irregular heartbeat. Unintentional weight loss, defined as a loss of 5% of body weight in one month or 10% in six months, is of significant concern in older adults.1,2 It’s a predictor of mortality, with 9% to 38% of older adults dying within one to 2 1/2 years of onset3 … Although cyproheptadine is more often used in cats, it is also frequently found in canine veterinary medicine. Weight gain is usually noted during the first few weeks of therapy. Most had lost weight on stimulant alone (mean weight loss was 2.1 kg, mean weight velocity was -19.3 g/day). Periactin is a brand name version of the prescription drug cyproheptadine. As it is an anti-depressant, the animal should be weaned off the drug over a period instead of ceasing abruptly. This drug is available at a higher level co-pay. Access your plan list on any device – mobile or desktop. Pediatric patients: 0.25 mg/kg orally per day (given in divided doses) OR 8 mg/m2 orally per day (given in divided doses) Most In adults with anorexia nervosa, up to 8 mg PO four times per day has been administered. -Patients who are nursing Cyproheptadine is more commonly used for dogs as a way of addressing allergic reactions and other related conditions. The paediatrician gave him Oraxin (cyproheptadine hydrochloride 2mg, peptone 25mg and lysine hydrochloride 150 mg). prescription products. Administration advice: Migraine. Drugs, 2003 By Mark D. Coggins, PharmD, CGP, FASCP Today’s Geriatric Medicine Vol. -Perennial/seasonal allergic rhinitis This medicine can cause you … Available for Android and iOS devices. -Some patients need up to 32 mg/day to attain relief. -Oral solution/syrup: Protect from light. Cyproheptadine may be prescribe to improve a person's appetite. Dosage for Cyproheptadine? -Dermatographism Cyproheptadine doses are based on weight (especially in children and teenagers), and any changes may affect the dose. All 21 gained weight taking concomitant cyproheptadine, with a … Safety and efficacy have not been established in patients younger than 2 years. -Cold urticaria 4 strengths of Cyproheptadine Twist-a-Dose Transdermal Gel are available, ranging from 1 mg/0.05ml to 4 mg/0.05ml. Adult dosing for cyproheptadine ranges from 4 mg to 20 mg per day. and formulary information changes. Most When given the drug proved effective and it reduced the child's hyperactivity and at present the child weighs 11 Kg (24 pounds 3 ounces). Data were analyzed for 21 other patients (age range 4-15 years) who continued with 4-8 mg of cyproheptadine nightly (mean final dose = 4.9 mg/day) for at least 14 days (mean duration = 104.7 days). Drug Type: Antihistamine. Wondering what your team does for dosage? Otherwise, no randomised control trial demonstrates the efficacy of Cyproheptadine on those patients. Medically reviewed by Drugs.com. /viewarticle/936501 The usual dose is 4 mg (1 tablet) two or three times a day adjusted as necessary to the size and response of the patient. CONTRAINDICATIONS: -Many patients require a daily dose of 12 to 16 mg. -Symptomatic prostatic hypertrophy -Allergic conjunctivitis due to inhalant allergens and foods Maintenance dose: 4 to 20 mg orally per day, given in divided doses. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -MAO inhibitor treatment This drug is available at a middle level co-pay. Although effective as an appetite stimulant for cats, cyproheptadine can cause adverse side effects such as agitation and excessive meowing/howling. Individual plans may vary Adding plans allows you to compare formulary status to other drugs in the same class. -Newborn or premature infants This website also contains material copyrighted by 3rd parties. commonly, these are "non-preferred" brand drugs or specialty This medication is an antihistamine intended for the management of allergies, but can cause increased appetite as a side effect. Storage requirements: -Allergic conjunctivitis due to inhalant allergens and foods 4 mg PO q8hr initially; maintenance: 4-20 mg/day, up to 32 mg/day divided q8hr in some patients; not to exceed 0.5 mg/kg/day, 2-4 mg PO q8hr initially; not to exceed 24 mg/day, 2 mg PO q6hr for one week; THEN 4 mg PO q6hr, 4-12 mg PO 1-2 hours before anticipated coitus or 1-16 mg/day, 12 mg initially PO, followed by 2 mg q2hr or 4-8 mg PO q6hr as needed to control symptoms, Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria), Advanced age is associated with reduced clearance and greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity; use lower end of dosage range (4 mg PO q12hr) for elderly patients, or administer less frequently, Renal impairment: Elimination is reduced in renal insufficiency; administer lower doses, and monitor closely, <2 years old: Safety and efficacy not established, 2-6 years old: 2 mg PO q8-12hr; not to exceed 12 mg/day, 7-14 years old: 4 mg PO q8-12hr; not to exceed 16 mg/day, Alternatively, total daily dose of 0.25 mg/kg or 8 mg/m², < 3 years: Safety and efficacy not established, >3 years and adolescents: 0.2-0.4 mg/kg/day PO divided BID; not to exceed 0.5 mg/kg/day, <13 years: Safety and efficacy not established, >13 years: 2 mg PO q6hr initially; increased to up to 8 mg q6hr over 3 weeks, Psychiatric/neurologic: CNS depression, drowsiness, sedation ranging from mild drowsiness to deep sleep (most frequent), dizziness, lassitude, disturbed coordination; less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia, Cardiovascular: Palpitation, tachycardia, palpitation, ECG changes (eg, widened QRS), arrhythmias (eg, extrasystole, heart block), hypotension, hypertension, dizziness, sedation, hypotension, GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare), Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin, Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis, Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness, Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness, Concomitant monoamine oxidase inhibitor therapy, Stenosing peptic ulcer, pyloroduodenal obstruction, Elimination reduced in renal insufficiency, Use with caution in cardiovascular disease, including hypertension, Elderly patients: Avoid use in elderly because of high incidence of anticholinergic effects; may exacerbate existing lower urinary conditions or benign prostatic hyperplasia; if used, administer at low end of dosage range, May cause CNS depression, which may impair mental abilities; use caution when operating heavy machinery, Use caution in cardiovascular disease, including hypertension and ischemic heart disease, Use with caution in patients with increased intraocular pressure, history of asthma or other chornic breathing disorders, or thyroid dysfunction, Nonanticholinergic antihistamines should be considered first for treatment of allergic reaction in the elderly (Beers criteria), Antihistamines may cause excitation in young children, Lactation: Excretion in milk unknown; contraindicated.